This companion report to the World Development Report (WDR) 2019: The Changing Nature of Work addresses the key themes of creating productive jobs and addressing the needs of those left behind. It builds on and contextualizes some of WDR 2019’s main messages to key specificities of the sub-Saharan Africa (SSA) region. It focuses on how global trends especially the adoption of digital technologies (DTs) may change the nature of work in SSA by creating new opportunities and challenges. The report is structured around three main issues that will shape the future of work in Africa, namely the human capital needs of a young and rapidly growing largely low-skilled labor force, the prevalence of informal workers and enterprises and the social protection policies to mitigate risks resulting from disruptions to labor markets. The report highlights important unanswered policy questions where new research, supplemented by new data, could yield learnings with high policy payoffs in the SSA context.